Science

Science

Read the results of the scientific studies supporting BeniCaros:
  • cRG-I selectively modulates human gut microbiota while promoting gut barrier integrity (van den Abbeele et al., 2020)

    Pre-clinical study demonstrating that BeniCaros can modulate beneficial gut microbiota, improve gut barrier integrity, and decreased inflammatory markers.

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  • Effect of Rhamnogalacturonan-I on Anti-Viral Response in Healthy Subjects (Lutter et al., 2021) (abstract)

    Clinical study in healthy adults showing that prophylactic intake of BeniCaros, as a dietary supplement, modulated immune responses to rhinovirus infection and decreased duration and severity of symptoms without any side effects. Abstract presented and published at American Thoracic Society (ATS) , full manuscript is currently in preparation.

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  • “Development of an affordable, sustainable and efficacious plant-based immunomodulatory food ingredient based on bell pepper or carrot RG-I pectic polysaccharides” (McKay et al., 2021)

    Clinical and pre-clinical studies demonstrating that dietary supplementation with BeniCaros is safe and effective, and has a dual mode of action: direct 1) immunomodulatory effect on phagocytosis and 2) gut microbiota modulation with enhanced production of beneficial microbial metabolites (short-chain fatty acids).

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  • “Consistent Prebiotic Effects of Carrot RG-I on the Gut Microbiota of Four Human Adult Donors in the SHIME® Model despite Baseline Individual Variability” (van den Abbeele et al. 2021)

    This study demonstrated that administration of cRG-I consistently modified the human microbiota despite the inherent interindividual variability between subjects. Levels of metabolites such as short-chain fatty acids (SCFA) that exert a beneficial effect on gut and immune health were increased as a result of the microbiota modulation. This study thus further confirms the dual mode of action of cRG-I on the host immune system and gut microbiota.

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  • “The Dietary Intake of Carrot-Derived Rhamnogalacturonan-I Accelerates and Augments the Innate Immune and Anti-Viral Interferon Response to Rhinovirus Infection and Reduces Duration and Severity of Symptoms in Humans in a Randomized Trial” (Lutter et al., 2021)

    Pivotal clinical study showing that Nutrileads’ proprietary carrot-derived Rhamnogalacturonan-I (cRG-I) fiber, accelerates protective anti-viral immune responses and reduces symptoms after an experimental infection with common cold virus in humans.

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  • Effects of Dietary Supplementation with Carrot-Derived Rhamnogalacturonan-I (cRG-I) on Accelerated Protective Immune Responses and Quality of Life in Healthy Volunteers Challenged with Rhinovirus in a Randomized Trial (Mckay et al, 2022)

    The aim of this paper is to elaborate on our initial findings that dietary supplementation with carrot-derived rhamnogalacturonan-I (cRG-I) accelerates and augments local innate immune and anti-viral interferon response to a rhinovirus-16 (RV16) infection and reduces the severity and duration of symptoms in humans.

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  • Ingestion, Immunity and Infection: Nutrition and Viral Respiratory Tract Infections

    The aim of this review is to describe the effects of a range different dietary components on anti- infective innate as well as adaptive immune responses and to propose mechanisms by which they may interact with the immune system in the respiratory tract. Several dietary components are described including the unique findings with rhamnogalacturonan-I (cRG-I) (Govers et al. 2022)

     

     

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