BeniCaros & benefits – nic 2

What is BeniCaros?

BeniCaros™ is an award-winning natural immune health ingredient. It is a unique polysaccharide (fiber) also known as rhamnogalacturonan-I (RG-I), derived from upcycled carrot pomace, a by-product of carrot juice production.  RG-I is a complex polysaccharide, a part of pectin that is a major component in the cell walls of all plants. The carrot derived cRG-I in BeniCaros is unlocked from the carrot cell wall through our proprietary extraction method.

BeniCaros has been developed as a natural food ingredient to train the body’s immune defense system and improve resistance to respiratory infections. BeniCaros was launched for formulation in dietary supplements and functional food and beverages in the US in October 2021.

The benefits of BeniCaros

BeniCaros has unique immune properties

Daily intake of BeniCaros helps to prepare your immune system to be fit all year round.

Clinically and scientifically proven

BeniCaros has been scientifically tested in high quality clinical trials to demonstrate its beneficial impact on a healthy immune system.

Natural

BeniCaros is naturally sourced and produced, with zero artificial additives.

Plant-derived

BeniCaros is a unique polysaccharide (fiber) that has been unlocked from the cell walls of carrots.

Upcycled

BeniCaros is upcycled from carrot pomace, a by-product of carrot juice production.

Broad applicability

BeniCaros can be easily added to most foods, beverages, and supplement formats without compromising on taste, odour, texture or ease of consumption.

BeniCaros is a health ingredient that addresses a major consumer need

Consumer understanding of immune health has increased over the past few years. This has also prompted more demand for products that deliver benefits for overall wellbeing, with a strong focus on products that support a healthy, balanced immune system.

Consumer interest in foods supporting immune health has increased worldwide [1]

Numbers represent percentages of people wanting products to support their immune health.

[1]. Innova Consumer Survey 2020, click here to find out more

NutriLeads develops innovative natural ingredients with clinically proven benefits such as supporting immune health

How BeniCaros works

How does the immune system work?

The immune system is the body’s surveillance system that responds to intruders, for example pathogens. It provides defense against the various challenges that we encounter every day, most of which are fought off by the immune system without us even noticing. An optimal functioning immune system is crucial to remain fit and to be able to enjoy life to its fullest. To respond to infections, the immune system raises the interconnected innate and adaptive protective responses. The innate immune response is the body’s first line of defense. It reacts quickly to any infectious agent without needing to first learn how to recognize specific pathogens. Effective innate immune responses limit the extent of an infection early on and can curb many infections before we are even aware that they are there.
The immune system helps to maintain our health. Good health starts with a balance between healthy lifestyle and good nutrition. Maintaining general well-being is important to consumers, who focus on adopting nutritional solutions and a healthy lifestyle to help support their health and wellness goals.

Why is it important to train the immune system?

Just like other parts of the body, the immune system needs to be nourished and trained to function properly and effectively. A fit immune system ensures the best outcomes: quick, appropriate, and effective responses against infections. Immune fitness helps the body to remain in a healthy balanced state, or quickly bounce back to it, when faced with daily challenges from potentially harmful agents.

Like the rest of the body, the immune system requires energy and micronutrients to perform its basic functions. And to be at its best, it also needs to be trained, for example by being exposed to specific patterns (signals) from the diet and the gut microbiota. Fibers reinforce a healthy crosstalk between the gut microbiota and the immune system. Just as we know that not all vitamins are alike, this also applies to fibers – not all fibers have the same characteristics or function. For a fit immune system nutritional deficiency (e.g., vitamin B6, C, D and Zn) should be supplemented and the immune system needs to be exposed to the appropriate training stimuli – for example in the gut where the immune system is exposed to the diet and the microbiota.

Clinical studies show that daily use of BeniCaros prepares your immune system to be fit

How does BeniCaros work?

BeniCaros is unique like no other immune ingredient on the market – a daily intake of just 0.3 g per day trains the immune system to be fit.

BeniCaros, when consumed for example as a dietary supplement or functional food, reaches the small intestine intact where it can be recognized by cells that are part of the immune system. This recognition is the first step towards training innate immune responsiveness.
BeniCaros then transits to the large intestine, where it is fermented by the gut microbiota and selectively stimulates the growth of beneficial microorganisms and leads to the increased production of beneficial metabolites such as short chain fatty acids. Short chain fatty acids can leave the gut (via the blood/circulation) and are known to interact with immune cells (all over the body), thereby influencing immune responsiveness.
The immune cells that are “trained” in the small intestine (also) migrate throughout the body towards other sites/organs including the respiratory tract, where they play an important role in the early response against infections. Because these trained immune cells can respond faster, people taking BeniCaros can experience less severe symptoms, and a shorter duration of the symptoms if they become infected, for example by a common cold virus.

BeniCaros has dual mode of action in influencing the immune system:

1. By directly simulating the innate immune system and
2. By indirectly impacting the immune system via gut microbiota modulation

BeniCaros mechanism of action

How BeniCaros is made

Natural upcycled supply chain

NutriLeads has succeeded in harnessing the health-giving power of natural plant compounds, extracting them from affordable and renewable crops, and developing them into evidence-based health ingredients.

BeniCaros is the first health ingredient available from NutriLeads, based on the company’s unique RG-I (rhamnogalacturonan-I) health ingredients platform. It is based on carrot RG-I, which is upcycled from carrot pomace, a by-product of carrot juice production.

Read more

STEP 1

Carrots are grown naturally by trusted farmers, ensuring traceability

STEP 2

The carrots are washed with water and steam peeled

STEP 3

The carrots are pressed to produce carrot juice and a side stream

STEP 4

The by-product, carrot pomace , is the starting material for BeniCaros

STEP 5

RG-I is extracted from the carrot pomace using NutriLead’s proprietary production process and dried to produce a powder concentrate

STEP 6

NutriLeads tests the powder to ensure RG-I content and activity

STEP 7

BeniCaros is ready to be incorporated into consumer products

Supported by science

NutriLeads is developing a portfolio of sustainable and natural ingredients to strengthen human health through nutrition.

NutriLeads’ team benefits from a rich and diverse expertise in research and development, production and commercialization of health ingredients, and is committed to maintaining the highest scientific standards.

BeniCaros has been taken through rigorous pre-clinical and clinical studies to demonstrate its safety and positive effect on human health and to gain regulatory approval for market access.

Read the results of the scientific studies supporting BeniCaros:

  • “The Dietary Intake of Carrot-Derived Rhamnogalacturonan-I Accelerates and Augments the Innate Immune and Anti-Viral Interferon Response to Rhinovirus Infection and Reduces Duration and Severity of Symptoms in Humans in a Randomized Trial” (Lutter et al., 2021)

    Pivotal clinical study showing that Nutrileads’ proprietary carrot-derived Rhamnogalacturonan-I (cRG-I) fiber, accelerates protective anti-viral immune responses and reduces symptoms after an experimental infection with common cold virus in humans.

    Download
  • “Consistent Prebiotic Effects of Carrot RG-I on the Gut Microbiota of Four Human Adult Donors in the SHIME® Model despite Baseline Individual Variability” (van den Abbeele et al. 2021)

    This study demonstrated that administration of cRG-I consistently modified the human microbiota despite the inherent interindividual variability between subjects. Levels of metabolites such as short-chain fatty acids (SCFA) that exert a beneficial effect on gut and immune health were increased as a result of the microbiota modulation. This study thus further confirms the dual mode of action of cRG-I on the host immune system and gut microbiota.

    Download
  • “Development of an affordable, sustainable and efficacious plant-based immunomodulatory food ingredient based on bell pepper or carrot RG-I pectic polysaccharides” (McKay et al., 2021)

    Clinical and pre-clinical studies demonstrating that dietary supplementation with BeniCaros is safe and effective, and has a dual mode of action: direct 1) immunomodulatory effect on phagocytosis and 2) gut microbiota modulation with enhanced production of beneficial microbial metabolites (short-chain fatty acids).

    Download
  • Effect of Rhamnogalacturonan-I on Anti-Viral Response in Healthy Subjects (Lutter et al., 2021) (abstract)

    Clinical study in healthy adults showing that prophylactic intake of BeniCaros, as a dietary supplement, modulated immune responses to rhinovirus infection and decreased duration and severity of symptoms without any side effects. Abstract presented and published at American Thoracic Society (ATS) , full manuscript is currently in preparation.

    Download

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Lorem ipsum dolor sit amet, consectetur adipiscing elit. Quisque eu dui quis justo consequat laoreet ac vitae augue. Integer ac arcu dolor. Sed tellus ex, hendrerit id odio vel, mattis pulvinar dui. In lobortis est eget accumsan placerat. Nam elit neque, maximus eu lacinia vitae, pellentesque vehicula sapien. Sed mollis, diam id feugiat dictum, elit massa vehicula est, nec laoreet sem tellus quis metus. Aliquam dapibus velit ut neque tincidunt porttitor.

Lorem ipsum dolor sit amet, consectetur?
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Quisque eu dui quis justo consequat laoreet ac vitae augue. Integer ac arcu dolor. Sed tellus ex, hendrerit id odio vel, mattis pulvinar dui. In lobortis est eget accumsan placerat. Nam elit neque, maximus eu lacinia vitae, pellentesque vehicula sapien. Sed mollis, diam id feugiat dictum, elit massa vehicula est, nec laoreet sem tellus quis metus. Aliquam dapibus velit ut neque tincidunt porttitor.

Lorem ipsum dolor sit amet, consectetur?
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Quisque eu dui quis justo consequat laoreet ac vitae augue. Integer ac arcu dolor. Sed tellus ex, hendrerit id odio vel, mattis pulvinar dui. In lobortis est eget accumsan placerat. Nam elit neque, maximus eu lacinia vitae, pellentesque vehicula sapien. Sed mollis, diam id feugiat dictum, elit massa vehicula est, nec laoreet sem tellus quis metus. Aliquam dapibus velit ut neque tincidunt porttitor.

Lorem ipsum dolor sit amet, consectetur?
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Quisque eu dui quis justo consequat laoreet ac vitae augue. Integer ac arcu dolor. Sed tellus ex, hendrerit id odio vel, mattis pulvinar dui. In lobortis est eget accumsan placerat. Nam elit neque, maximus eu lacinia vitae, pellentesque vehicula sapien. Sed mollis, diam id feugiat dictum, elit massa vehicula est, nec laoreet sem tellus quis metus. Aliquam dapibus velit ut neque tincidunt porttitor.

Lorem ipsum dolor sit amet, consectetur?
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Quisque eu dui quis justo consequat laoreet ac vitae augue. Integer ac arcu dolor. Sed tellus ex, hendrerit id odio vel, mattis pulvinar dui. In lobortis est eget accumsan placerat. Nam elit neque, maximus eu lacinia vitae, pellentesque vehicula sapien. Sed mollis, diam id feugiat dictum, elit massa vehicula est, nec laoreet sem tellus quis metus. Aliquam dapibus velit ut neque tincidunt porttitor.

Lorem ipsum dolor sit amet, consectetur?
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Quisque eu dui quis justo consequat laoreet ac vitae augue. Integer ac arcu dolor. Sed tellus ex, hendrerit id odio vel, mattis pulvinar dui. In lobortis est eget accumsan placerat. Nam elit neque, maximus eu lacinia vitae, pellentesque vehicula sapien. Sed mollis, diam id feugiat dictum, elit massa vehicula est, nec laoreet sem tellus quis metus. Aliquam dapibus velit ut neque tincidunt porttitor.

Lorem ipsum dolor sit amet, consectetur?
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Quisque eu dui quis justo consequat laoreet ac vitae augue. Integer ac arcu dolor. Sed tellus ex, hendrerit id odio vel, mattis pulvinar dui. In lobortis est eget accumsan placerat. Nam elit neque, maximus eu lacinia vitae, pellentesque vehicula sapien. Sed mollis, diam id feugiat dictum, elit massa vehicula est, nec laoreet sem tellus quis metus. Aliquam dapibus velit ut neque tincidunt porttitor.

Lorem ipsum dolor sit amet, consectetur?
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Quisque eu dui quis justo consequat laoreet ac vitae augue. Integer ac arcu dolor. Sed tellus ex, hendrerit id odio vel, mattis pulvinar dui. In lobortis est eget accumsan placerat. Nam elit neque, maximus eu lacinia vitae, pellentesque vehicula sapien. Sed mollis, diam id feugiat dictum, elit massa vehicula est, nec laoreet sem tellus quis metus. Aliquam dapibus velit ut neque tincidunt porttitor.

Lorem ipsum dolor sit amet, consectetur?
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Quisque eu dui quis justo consequat laoreet ac vitae augue. Integer ac arcu dolor. Sed tellus ex, hendrerit id odio vel, mattis pulvinar dui. In lobortis est eget accumsan placerat. Nam elit neque, maximus eu lacinia vitae, pellentesque vehicula sapien. Sed mollis, diam id feugiat dictum, elit massa vehicula est, nec laoreet sem tellus quis metus. Aliquam dapibus velit ut neque tincidunt porttitor.

Lorem ipsum dolor sit amet, consectetur?
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Quisque eu dui quis justo consequat laoreet ac vitae augue. Integer ac arcu dolor. Sed tellus ex, hendrerit id odio vel, mattis pulvinar dui. In lobortis est eget accumsan placerat. Nam elit neque, maximus eu lacinia vitae, pellentesque vehicula sapien. Sed mollis, diam id feugiat dictum, elit massa vehicula est, nec laoreet sem tellus quis metus. Aliquam dapibus velit ut neque tincidunt porttitor.

Lorem ipsum dolor sit amet, consectetur?
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Quisque eu dui quis justo consequat laoreet ac vitae augue. Integer ac arcu dolor. Sed tellus ex, hendrerit id odio vel, mattis pulvinar dui. In lobortis est eget accumsan placerat. Nam elit neque, maximus eu lacinia vitae, pellentesque vehicula sapien. Sed mollis, diam id feugiat dictum, elit massa vehicula est, nec laoreet sem tellus quis metus. Aliquam dapibus velit ut neque tincidunt porttitor.

Lorem ipsum dolor sit amet, consectetur?
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Quisque eu dui quis justo consequat laoreet ac vitae augue. Integer ac arcu dolor. Sed tellus ex, hendrerit id odio vel, mattis pulvinar dui. In lobortis est eget accumsan placerat. Nam elit neque, maximus eu lacinia vitae, pellentesque vehicula sapien. Sed mollis, diam id feugiat dictum, elit massa vehicula est, nec laoreet sem tellus quis metus. Aliquam dapibus velit ut neque tincidunt porttitor.

Supported by science

FAQs

Supported by science

BeniCaros™ is an award-winning natural immune health ingredient. It is a unique polysaccharide derived from upcycled carrot pomace, a by-product of carrot juice production. This fiber is also known as rhamnogalacturonan-I (RG-I), and we define the specific carrot-derived RG-I in the NutriLeads ingredient by the trade name BeniCaros (commercial name)

RG-I (Rhamnogalacturonan-I) is a complex polysaccharide. It is part of pectin, which is a major component in the cell walls of all plants. It is also referred to as the complex part or the hairy part of the pectin and it is precisely this complexity of the compound that is responsible for most of its activity. We developed the proprietary extraction method that enables us to unlock the goodness of RG-I from the cell wall of carrot pomace.

BeniCaros™ (cRG-I) trains your immune system to be at its best when it matters the most. Clinical studies have shown that BeniCaros™ helps train your healthy immune system and put it in the best position to respond to viruses faster.

When consumed as a dietary supplement or an ingredient in a functional food, for example, BeniCaros™ reaches the small intestine intact, where it can be recognized by cells that are part of the innate immune system. This recognition is the first step towards training the body’s immune responsiveness.
BeniCaros™ then moves to the large intestine, where it is fermented by gut microbiota. It selectively stimulates the growth of beneficial microorganisms and leads to the increased production of metabolites such as short chain fatty acids (SCFA)s. SCFAs can leave the gut and move around the body via circulation and can also interact with immune cells, thereby influencing immune responsiveness.
The immune cells recognized and ‘trained’ by BeniCaros™ in the small intestine can move throughout the body. When they reach the respiratory tract (or other locations), they play an important role in the early immune response against infections.
Because trained immune cells can respond faster, people consuming BeniCaros™ can experience less severe symptoms for a shorter duration if they are infected by a common cold virus, for example.

It’s not that simple. BeniCaros™ (cRG-I) is tightly bound inside the cell walls of carrots, so it needs to be unlocked before it can have an effect in the body. Our proprietary extraction method unlocks the goodness of cRG-I from carrot pomace.

No, BeniCaros™ is not a micronutrient, it is a complex polysaccharide (fiber). It does help to support the immune system, albeit in a different way to micronutrients. The immune system needs vitamins and minerals to be able to function normally. However, to be at its best, the immune system also needs to be trained. BeniCaros™ trains the immune system and this helps to support innate immune responses.
You can read more here:

Based on our clinical studies, we recommend a dose of 0.3 g/day.

Healthy individuals older than 18 years.

BeniCaros™ does display prebiotic properties. However, to be officially classed as a prebiotic, we need to show that the effects of BeniCaros™ on gut microbiota modulation can be directly linked to a health benefit. We are currently conducting studies to show this.

BeniCaros™ is safe and can be taken every day. BeniCaros™ has been investigated in several clinical studies, which showed it is safe for use by healthy adults.

Several clinical studies have demonstrated that daily consumption of BeniCaros™ is safe for healthy adults. No side effects have been associated with the recommended daily intake. Individuals with serious medical conditions or taking prescription medications should always consult a healthcare practitioner before taking BeniCaros™.

Materials that were once considered waste are given a new lease of life in the circular economy through upcycling. In this case, the side stream from carrot juice production is carrot pomace. This material is often discarded or used for animal feed, while it still contains valuable ingredients that have added value for human health, like cRG-I. We upcycle carrot pomace to produce BeniCaros™.

FAQs

BeniCaros™ is an award-winning natural immune health ingredient. It is a unique polysaccharide derived from upcycled carrot pomace, a by-product of carrot juice production. This fiber is also known as rhamnogalacturonan-I (RG-I), and we define the specific carrot-derived RG-I in the NutriLeads ingredient by the trade name BeniCaros (commercial name)

RG-I (Rhamnogalacturonan-I) is a complex polysaccharide. It is part of pectin, which is a major component in the cell walls of all plants. It is also referred to as the complex part or the hairy part of the pectin and it is precisely this complexity of the compound that is responsible for most of its activity. We developed the proprietary extraction method that enables us to unlock the goodness of RG-I from the cell wall of carrot pomace.

BeniCaros™ (cRG-I) trains your immune system to be at its best when it matters the most. Clinical studies have shown that BeniCaros™ helps train your healthy immune system and put it in the best position to respond to viruses faster.

When consumed as a dietary supplement or an ingredient in a functional food, for example, BeniCaros™ reaches the small intestine intact, where it can be recognized by cells that are part of the innate immune system. This recognition is the first step towards training the body’s immune responsiveness.
BeniCaros™ then moves to the large intestine, where it is fermented by gut microbiota. It selectively stimulates the growth of beneficial microorganisms and leads to the increased production of metabolites such as short chain fatty acids (SCFA)s. SCFAs can leave the gut and move around the body via circulation and can also interact with immune cells, thereby influencing immune responsiveness.
The immune cells recognized and ‘trained’ by BeniCaros™ in the small intestine can move throughout the body. When they reach the respiratory tract (or other locations), they play an important role in the early immune response against infections.
Because trained immune cells can respond faster, people consuming BeniCaros™ can experience less severe symptoms for a shorter duration if they are infected by a common cold virus, for example.

It’s not that simple. BeniCaros™ (cRG-I) is tightly bound inside the cell walls of carrots, so it needs to be unlocked before it can have an effect in the body. Our proprietary extraction method unlocks the goodness of cRG-I from carrot pomace.

No, BeniCaros™ is not a micronutrient, it is a complex polysaccharide (fiber). It does help to support the immune system, albeit in a different way to micronutrients. The immune system needs vitamins and minerals to be able to function normally. However, to be at its best, the immune system also needs to be trained. BeniCaros™ trains the immune system and this helps to support innate immune responses.
You can read more here:

Based on our clinical studies, we recommend a dose of 0.3 g/day.

Healthy individuals older than 18 years.

BeniCaros™ does display prebiotic properties. However, to be officially classed as a prebiotic, we need to show that the effects of BeniCaros™ on gut microbiota modulation can be directly linked to a health benefit. We are currently conducting studies to show this.

BeniCaros™ is safe and can be taken every day. BeniCaros™ has been investigated in several clinical studies, which showed it is safe for use by healthy adults.

Several clinical studies have demonstrated that daily consumption of BeniCaros™ is safe for healthy adults. No side effects have been associated with the recommended daily intake. Individuals with serious medical conditions or taking prescription medications should always consult a healthcare practitioner before taking BeniCaros™.

Materials that were once considered waste are given a new lease of life in the circular economy through upcycling. In this case, the side stream from carrot juice production is carrot pomace. This material is often discarded or used for animal feed, while it still contains valuable ingredients that have added value for human health, like cRG-I. We upcycle carrot pomace to produce BeniCaros™.